Gene: CD47; CD47 molecule: Aliases: IAP, OA3, MER6 : Location: 3q13.12: Summary: This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix.

11 Jan 2017 Cluster of differentiation 47 (CD47) (also known as integrin-associated protein) is a ubiquitously expressed glycoprotein of the immunoglobulin 

Expression and Regulation of the Cell Surface Proteins CD47 and SIRPα in Resident Expression of weight and aggression regulating genes in Drosophila  proteinbearbetning och vikning (CANX, PSENEN) och det integrin-associerade protein, CD47, som modulerar cellaktivering och vidhäftning. of using gene therapy to prevent and/or ameliorate autoimmune diseases. Mattias Olsson (Midterm seminar), Umeå university, “Role of the CD47/SIRPα  (73) BioNTech Cell & Gene Therapies GmbH, An der Goldgrube (54) ANTI-CD47 ANTIBODIES AND METHODS OF USE THEREOF. 2007. undefined. Umeå University medical dissertations,Role of the CD47/SIRPα-interaction in regulation of.

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Description of CD47 CRISPR guide RNA. Search for other guide RNAs . The CD47 CRISPR guide RNA sequences shown above were designed by the laboratory of Feng Zhang at the Broad Institute* in order to efficiently target the CD47 gene with minimal risk of off-target Cas9 binding elsewhere in the genome. Transcriptional control of the CD47 gene is incompletely understood and has only been studied in the context of neuronal development, where transcription of CD47 and concomitant neurite outgrowth relies on the transcription factor α-Pal/NRF-1 (Chang and Huang, 2004; Chang et al., 2005). NCBI Description of CD47 This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction.

lnc-CD47-10: RNA Gene: 4: GC03M107935: 6.73: 14: RHD: Rh Blood Group D Antigen: Protein Coding: 42: GC01P025272: 6.30: 15: LINC00636: Long Intergenic Non-Protein Coding RNA 636: RNA Gene: 17: GC03P107883: 6.26: 16: PTPN11: Protein Tyrosine Phosphatase Non-Receptor Type 11: Protein Coding: 54: GC12P112418: 6.22: 17: CD44: CD44 Molecule (Indian Blood Group) Protein Coding: 48: GC11P035139: 6.10: 18: ENSG00000279277

CD47 knockout mice were compared against matching wildtype mice. CD47 (IAP, MER6, OA3) protein expression summary.

CD47 is a cell surface glycoprotein that helps mediate neutrophil transmigration across blood vessels. The present study was performed to determine whether absence of the CD47 gene decreases focal ischemic brain damage. Mice were subjected to 90 min middle cerebral artery occlusion. CD47 knockout mice were compared against matching wildtype mice.

AE1 Anion Exchanger. AE1 Chloride Bicarbonate Exchanger. AE1 Chloride-Bicarbonate Exchanger. protein som överuttrycks på metastaserade prostatacancerceller. Därutöver är torer, neoantigenvacciner och CD47-blockad3.

- 44 s. : ill. Role of the CD47/SIRP-interaction in regulation of system : distribution  wnt4 protein · wnt3 protein · wnt2-protein · wnt1-protein nested genes · nervsystemet · nervändslut cd47-antigener · cd46-antigener · cd45-antigener Hemoglobin (Hb) är ett tetrameriskt protein som består av olika kombinationer av E-selektin, leukocyt-ytantigen CD47 och aVP3-integrin) och exponerade  Genetic Signatures Limited GSS.AX / GSS DE / CD47 GY 10% 8 0.3% ComStage Gene Techno Science Company Limited 4584.T / 4584  Analysen har publicerats online i Amyloid: The Journal of Protein Folding Disorders. Genom att behandla med blockerande antikroppar mot CD47 kunde man  are not mediated by repression of apmediated gene activity, which has beenobserved for the retinoids. A mab to cd47 had no such effect. CD47 (C luster of D ifferentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene.
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CD47 (HGNC Symbol) Synonyms. IAP, MER6, OA3: Description.

Gene Symbol: CD47: Entrez Gene ID: 961: Full Name: CD47 molecule: Synonyms: IAP,MER6,OA3: General protein information: Preferred Names. CD47 molecule. Names. leukocyte surface antigen CD47 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) CD47 glycoprotein Rh-related antigen antigen identified by monoclonal antibody 1D8 Believing that CD47 might hold the key to completely shutting down rejection, the researchers loaded the CD47 gene into a virus, which delivered extra copies of the gene into mouse and human stem cells in which the MHC proteins had been knocked out.
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In contrast, antisense Cd47 knockdown or gene disruption resulted in a dose dependent accumulation of immature and mature NK cells in spleen. Results identify Cd47 as a cell-intrinsic and systemic regulator of NK cell homeostasis and NK cell function in responding to a viral infection.

CD47 is a cell surface glycoprotein that helps mediate neutrophil transmigration across blood vessels.

CD47 is the latest immuno-oncology target and multiple companies are 076 - Krystal Biotech's NOVEL Gene Therapy for Rare Diseases | Interview with WX 

0.47. -0.40. CD47. 0.21.

3 Oct 2016 Methods: MCF-7 breast cancer cells were transfected with plasmid pcDNA3.4- CD47 containing the CD47 gene. The stemness of the transduced  29 Jun 2016 CD47 is a cell-surface molecule that promotes immune evasion by engaging signal-regulatory protein alpha (SIRPα), which serves as an  19 Apr 2019 CD47,or Integrin-associated protein (IAP), is first discovered in a study aimed at studying integrin αvβ3. CD47,or Integrin-associated protein (IAP), is first discovered in a study aimed at studying integrin αvβ3.